Genomic analysis of therapy-related acute promyelocytic leukemias arising after malignant and non-malignant disorders
نویسندگان
چکیده
منابع مشابه
Therapy-Related Acute Myeloid Leukemias
Therapy-related acute myeloid leukemia (t-AML) is a heterogeneous group of myeloid neo‐ plasms occurring as an overwhelming complication in patients receiving previous cytotoxic chemotherapy and/or radiation therapy used to treat haematopoietic or solid malignancies or associated with immunosuppressive treatment for non-neoplastic rheumatologic/autoim‐ mune diseases or solid organ transplantati...
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Acute promyelocytic leukemia (APL) should be distinguished from other subtypes of acute myeloid leukemia (AML) because of the increased risk of disseminated intravascular coagulation (DIC) and its response to arsenic compounds and retinoids. Some cases of AML seem morphologically similar to the microgranular variant of APL (French-AmericanBritish [FAB] AML-M3v) but lack the t(15;17). We evaluat...
متن کاملSerum protein changes in malignant diseases. I. The acute leukemias.
MONG the profound effects of malignant neoplasia are changes of serum protein components,’4 but the significance of these changes is poorly understood. The acute leukemias were selected for further study because the rapid course and the ability to induce complete remission in the disease seemed to offer opportunity for detailed observations. To delineate the effects due solely to acute leukemia...
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ژورنال
عنوان ژورنال: American Journal of Hematology
سال: 2014
ISSN: 0361-8609
DOI: 10.1002/ajh.23646